An Immunological Study of Native, Denatured, and Reversed Serum Albumin
نویسنده
چکیده
Native and reversed horse serum albumin are indistinguishable when tested immunologically by means of the precipitin reaction.
منابع مشابه
Antigenic Properties of Native and Regenerated Horse Serum Albumin
Comparative immunological measurements have been carried out on crystalline horse serum albumin in the native state and after regeneration from 8 M urea solutions. The mean antigenic activity of the regenerated protein has been found to be less than 10 per cent of that of the native, whereas both antigens proved to be immunologically equivalent. The problem of the relation between protein denat...
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One of the characteristic manifestations of biological activity of proteins resides in their ability to elicit antibody formation. While the activity of certain immune bodies, as well as that of enzymes, or viruses, is known to be destroyed by processes causing protein denaturation, the relation between denaturation and antigenicity is only vaguely understood. I t has been reported that denatur...
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Recent work in this laboratory has shown that the thermal stability of human serum albumin solutions, as measured nephelometrically and by the cloud point method (l), is increased by additions of salts of the lower fatty acids (1, 2). These results engendered an interest in other methods of measuring changes which may occur when the protein solutions are heated with or without added stabilizing...
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Several studies (2-6) of the hydrolysis of proteins by proteolytic eneymes have led to the suggestion that only denatured forms of the substrate are acted on; and that where an equilibrium between native (N) and denatured (D) forms, N $ D, is not spontaneous, the initial action of a protease may be a nonhydrolytic denaturation of native substrate. Green and Neurath (7) have suggested that nativ...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 58 شماره
صفحات -
تاریخ انتشار 2003